Key result
Aged mouse soleus muscles show ~21% lower isometric force, unexplained by phosphorus metabolites, pH, or myosin.
Why the study?
The mechanisms underlying muscle weakness in aged mice, including changes in phosphorus metabolite levels and myosin isoforms, were unclear.
Population
Isolated soleus and EDL muscles from young (6 month) and aged (28 month) mice
Comparison
Young versus aged mouse muscles
Design
Comparative biochemical and mechanical analysis study
Authors
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Age-related force loss independent of metabolites or isoforms; leaves open intrinsic contractile mechanisms in sarcopenia models.
Effect estimate: 21 +/- 5% lower
Phillips et al. (1993) studied Muscle weakness in aging (n=20). Aged (28 month old) vs. Young (6 month old) was evaluated on Isometric force per unit cross-sectional area (21 +/- 5% lower). Aged mouse soleus muscles had 21 +/- 5% lower isometric force than young muscles, a weakness not explained by changes in phosphorus metabolite levels, intracellular pH, or myosin isoforms.
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