Effects of Phlorizin on Glucose Kinetics in the Bovine

Glucose excretion from phlorizin was established in calves given different diets and/or different phlorizin doses; the ability of phlorizin to alter gluconeogenesis then was investigated. In calves fed hay, maximum glucose excretion of up to 313 g/day was caused by about 2 g of phlorizin per day. When calves were given only single doses of phlorizin subcutaneously, there was an increased glucose excretion with each increase in phlorizin up to 2 g with either a hay or a grain diet. At all phlorizin dosages, calves fed a high-grain diet had over two times greater glucose excretion than those fed hay. In three grain-fed calves where phlolSzin caused an average glucose excretion of 360 g/day, the only parameter of glucose kinetics that changed from control calves not given phlorizin was irreversib!e loss, which increased 8.2 g/h. Neither pool size nor total entry rate was affected. Phlorizin did not increase gluconeogenesis in fed ruminants.