A nonsteroidal estrogen antagonist, CI‐628, was administered orally to female beagle dogs on days 1–15 following mating. Dosages of 0.5, 1, 2, and 5 mg/kg effectively blocked pregnancy; six litters were whelped after 0.125 or 0.25 mg/kg in which various defects were present in pups of three litters.
No takes yet. Share an insight, caveat, or question.
Schardein et al. (1973) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: