Serum Hepatitis B Viral DNA in Acute Viral Hepatitis B

Brief Reports1 June 1989Serum Hepatitis B Viral DNA in Acute Viral Hepatitis BTse-Ling Fong, MD, Evangelos A. Akriviadis, MD, Sugantha Govindarajan, MD, Boontar Valinluck, MS, Allan G. Redeker, MDTse-Ling Fong, MDSearch for more papers by this author, Evangelos A. Akriviadis, MDSearch for more papers by this author, Sugantha Govindarajan, MDSearch for more papers by this author, Boontar Valinluck, MSSearch for more papers by this author, Allan G. Redeker, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-11-936 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is no way to identify which patients with acute hepatitis B infection will recover and which will become chronic carriers. Several studies (1-3) noted absence of serum hepatitis B viral DNA (HBV-DNA) in most patients with acute hepatitis B during the period of clinical symptoms. However HBV-DNA was consistently detectable in patients who became chronic carriers. Serum HBV-DNA was undetectable in acute fulminant hepatitis B, wherein survivors invariably clear hepatitis B surface antigen (HBsAg) (4). Our retrospective study compared the course of serum HBV-DNA in patients with acute hepatitis B virus infection who cleared HBsAg within 6 months and...References1. LokKarayiannisJowett APT. Studies of HBV replication during acute hepatitis followed by recovery and acute hepatitis progressing to chronic disease. J Hepatol. 1985;1:671-9. CrossrefMedlineGoogle Scholar2. KrogsgaardKrygerAldershvileAndersonBrechot KPJPC. Hepatitis B virus DNA in serum from patients with acute hepatitis B. Hepatology. 1985;1:10-3. CrossrefGoogle Scholar3. PontissoBortolottiSchiavonChemelloAlbertiRealdi PFELAG. Serum hepatitis B virus DNA in acute hepatitis type B. Digestion. 1986;34:46-50. CrossrefMedlineGoogle Scholar4. De CockGovindarajanValinluckRedeker KSBA Hepatitis B virus DNA in fulminant hepatitis B. Ann Intern Med. 1986;105:546-7. LinkGoogle Scholar5. ShafritzLiebermanIsselbacherWands DHKJ. Monoclonal radioimmunoassays for hepatitis B surface antigen: demonstration of hepatitis B virus DNA or related sequences in serum and viral epitopes in immune complexes. Proc Natl Acad Sei USA. 1982; 79:5675-9. CrossrefMedlineGoogle Scholar6. Redeker A. Viral hepatitis: clinical aspects. Am J Med Sci. 1975;270:9-16. CrossrefMedlineGoogle Scholar7. TassopoulosPapaevangelouSjogenRoumeliotou-KarayannisGerin NGMAJ. Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults. Gastroenterology. 1987;92:1844-50. CrossrefMedlineGoogle Scholar8. SeeffBeebeHoofnagle LGJ. A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army. N Engl J Med. 1987;316:965-70. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Tse-Ling Fong, MD; Evangelos A. Akriviadis, MD; Sugantha Govindarajan, MD; Boontar Valinluck, MS; Allan G. Redeker, MDAffiliations: From the University of Southern California School of Medicine, Ranchos Los Amigos Medical Center, Downey, California. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManagement of Fulminant Hepatitis BManagement of severe acute to fulminant hepatitis B: to treat or not to treat or when to treat?Kinetics of Acute Hepatitis B Virus Infection in HumansCharacteristics of the early phase of chronicity in acute hepatitis B infectionCould serum HBV DNA level in the early phase of acute hepatitis predict evolution to chronic HBV carriage?High levels of viral replication during acute hepatitis B infection predict progression to chronicityAn enzyme-linked (alkaline phosphatase) oligonucleotide probe for the detection of serum hepatitis B virus DNADiagnostic sérologique de l'infection par les virus des hépatites B et deltaHepatitis 1990 1 June 1989Volume 110, Issue 11Page: 936-937KeywordsAcute hepatitis BDNAHepatitis BHepatitis B surface antigenInfectious hepatitisLiverRetrospective studies ePublished: 1 December 2008 Issue Published: 1 June 1989 PDF downloadLoading ...