Why the study?
Cardiovascular risk burden is linked to CVD and cognitive decline, but its association with disability and mediating pathways remain unclear.
Does a higher cardiovascular risk burden increase the risk and progression of disability in older adults?
Population
1480 older adults without disabilities from the Rush Memory and Aging Project
Comparison
Framingham general cardiovascular risk score categorized into tertiles
Design
Prospective cohort study with mediation analysis
Follow-up
Up to 21 years
Authors
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May accelerate disability in older adults with high CV risk; leaves open whether modification alters functional trajectories.
Does a higher cardiovascular risk burden increase the risk and progression of disability in older adults?
Higher cardiovascular risk burden is associated with an increased risk and accelerated progression of disability in older adults, partially mediated by CVD accumulation and cognitive decline.
Cui et al. (2020) studied this question.
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