Why the study?
Does a NO-rich diet prevent lifestyle-related diseases and vascular endothelial dysfunction?
Does a NO-rich diet prevent lifestyle-related diseases and vascular endothelial dysfunction?
Dietary nitrate and nitrite from fruits and vegetables may serve as a backup system for NO generation, offering an inexpensive and practical strategy to prevent vascular endothelial dysfunction and lifestyle-related diseases.
Answers are grounded in this paper and cite their sources.
May support nitrate-rich diets for endothelial health; leaves open RCTs to confirm disease prevention.
Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases.
No takes yet. Share an insight, caveat, or question.
Kobayashi et al. (2015) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: