Metrnl plays a crucial role in the regulation of glycolipid metabolism

An imbalance in the metabolism of glycolipids largely causes numerous metabolic diseases that negatively affect human health. Metrnl plays an important role in glycolipid metabolism and regulates glucose and lipid metabolism through multiple mechanisms. However, the expression level of Metrnl in diseases related to glycolipid metabolism remains controversial. Metrnl can increase the utilization of glucose by tissue cells in glucose metabolism and reduce the adverse effects of a high-glucose environment on the body; in lipid metabolism, it can affect the composition and level of blood lipids, reduce the accumulation of fat, and promote the browning of white fat. The clinical efficacy of exogenously administered recombinant Metrnl needs to be further investigated and verified. This review presents an overview of Metrnl, emphasizing its role in glycolipid metabolism and its association with related diseases. It offers a theoretical foundation for the clinical treatment of glycolipid metabolism-related conditions.