An Inverted Metal-Organic Framework with Compartmentalized Cavities Constructed by Using an Organic Bridging Unit Derived from the Solid State We are grateful to the National Science Foundation (CAREER Award, L.R.M., DMR-0133138) and the University of Iowa for funding. Acknowledgement is also made to the Donors of The Petroleum Research Fund, administered by the American Chemical Society, for support of this research.

Gridlock: A porous metal–organic framework with an interior tailored supramolecularly with organic groups is described (see structure; two grids have been differentiated using cyan and gray, while the yellow spheres represent included methyl groups). The approach relies on inverting the role of a secondary building unit (SBU) and an organic linker such that the organic linker serves as a node and the SBU serves as a linear bridge. The organic node used to construct the framework has been obtained by way of a template-directed solid-state organic synthesis.