Why the study?
Do higher serum vitamin D levels reduce carotid atherosclerosis in Korean adults?
Do higher serum vitamin D levels reduce carotid atherosclerosis in Korean adults?
Serum vitamin D deficiency is strongly associated with the presence of carotid plaque and increased carotid intima-media thickness in Korean adults, suggesting a potential link between vitamin D status and subclinical atherosclerosis.
Vitamin D deficiency was associated with carotid plaque; leaves open causal effects and need for prospective trials.
The present study investigated the associations between serum vitamin D levels and carotid intima-media thickness (CIMT), carotid plaque and atherosclerosis in 71 Korean adults. CIMT and the presence of carotid plaque were assessed with a high-resolution B-mode ultrasound system, and carotid atherosclerosis was defined as a mean CIMT value >0.9 mm or the presence of carotid plaque. A vitamin D deficiency was associated with the presence of carotid plaque (adjusted odds ratio [aOR]: 9.25, 95% confidence interval [CI]: 1.52-56.3; p = 0.016). As serum vitamin D levels increased, the presence of high-risk carotid plaque decreased (aOR: 0.84, 95%CI: 0.72-0.99; p = 0.039). Serum vitamin D levels was negatively associated with carotid atherosclerosis (aOR: 0.86, 95%CI: 0.76-0.97; p = 0.018). Further studies are needed to investigate whether vitamin D supplementation would be effective for the prevention of atherosclerosis and cardiovascular diseases.
No takes yet. Share an insight, caveat, or question.
Choi et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: