Treatment of hepatic metastases by cryotherapy and regional cytotoxic perfusion.

Treatment of hepatic metastases by cryotherapy and regional cytotoxic perfusion Cryotherapy was probably first used to treat tumours by Arnott' almost 150 years ago. Much scientific work was done more than 20 years ago, including findings on the effect of repeated freeze/thaw cycles in the liver.2 Hepatic cryotherapy was done by direct application of liquid nitrogen at -196C,