An Orthogonal Double‐Linker Resin Facilitates the Efficient Solid‐Phase Synthesis of Complex‐Type N‐Glycopeptide Thioesters Suitable for Native Chemical Ligation

A safety catch combined with a Rink-amide linker allowed convenient monitoring (LC–MS) and optimization of several key reactions in a solid-phase synthesis of the building block A for the glycoprotein RNase B. The native chemical ligation of A and B delivered the glycosylated RNase B fragment 30–68.