February 1, 1998Journal of VirologyOpen Access

A Protein Linkage Map of the P2 Nonstructural Proteins of Poliovirus

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Population

Yeast two-hybrid system and in vitro models studying poliovirus type 1 (Mahoney) P2 nonstructural proteins

Comparison

Mutagenesis of 2B protein vs Wild-type 2B protein

Design

Preclinical

Authors

ACAndrea CuconatiRutgers, The State University of New Jersey WXWenkai XiangNational University of Defense Technology FLFrederick LahserMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

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Implication

Highlights potential antiviral target in poliovirus; leaves open validation across enteroviruses and in humans.

Structured PICO

Population

Yeast two-hybrid system and in vitro models studying poliovirus type 1 (Mahoney) P2 nonstructural proteins

Intervention

Mutagenesis of 2B protein (transdominant-negative mutants, missense mutations, truncations, frameshifts)

Comparator

Wild-type 2B protein

Outcome

Protein-protein interactions among P2 nonstructural cleavage productssurrogate

The study maps the interactions of poliovirus P2 nonstructural proteins and demonstrates that 2B multimerization is essential for viral RNA replication.

Cite This Study

Cuconati et al. (1998) studied this question.

synapsesocial.com/papers/6a82a6ea72d82bb027239bc1 https://doi.org/10.1128/jvi.72.2.1297-1307.1998

View Full Paper

Ask AI

Bookmark

A Protein Linkage Map of the P2 Nonstructural Proteins of Poliovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Protein Linkage Map of the P2 Nonstructural Proteins of Poliovirus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider