Immune Response to a Hapten Coupled to a Nonimmunogenic Carrier

Cooperation between two or more cell types is an essential feature of the immune response to some antigens (1). These cell types are commonly referred to as thymus derived (T) and bone marrow derived (B). Furthermore, in the immune response to a hapten bound to a carrier protein these two cell types perform quite separate and distinct cooperative functions (2-5). The T cell is responsible for recognition of the carrier and has been termed the helper cell (5, 6) ; the B cell synthesizes antibody to the hapten.