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Summary Following toxin-antitoxin injections a noteworthy proportion of human subjects became hypersensitive to horse serum as shown by specific endermal reactions. The pertinence of this observation to serum therapy in general is discussed. In order to avert the widespread and disadvantageous influence which such induced hypersensitiveness is likely to exert upon the use of therapeutic horse sera, it is recommended that some other animal be chosen for the production of that antitoxin which is destined for use in toxin-antitoxin mixtures.
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Sanford B. Hooker (1924) studied this question.
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