Why the study?
Evidence substantiates the beneficial effects of enhancing the ACE2/Ang-(1-7)/Mas axis across pathological conditions in experimental models, prompting a review of current strategies, limitations, and challenges for developing ACE2 as a therapeutic agent.
Design
Review
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ACE2 enhancement shows experimental promise in cardiovascular models; leaves open clinical translation amid SARS-CoV entry concerns.
This review highlights the therapeutic potential of enhancing the ACE2/Ang-(1-7)/Mas axis while acknowledging challenges such as its role as a SARS-CoV entry receptor.
A 2020 study studied this question.
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