Population
Human osteosarcoma (OS) and cardiomyocyte cell lines, and mice
Design
Preclinical
Follow-up
1 month (in vivo), 24 h (in vitro)
Authors
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May guide mechanistic studies of doxorubicin cardiotoxicity; leaves open translation from animal models to clinical practice.
Doxorubicin induces both apoptotic and autophagic responses in cardiomyocytes, with differing predominant pathways in vitro versus in vivo.
Tacar et al. (2014) studied this question.
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