November 25, 2013Human & Experimental Toxicology

Oxidative stress on cardiotoxicity after treatment with single and multiple doses of doxorubicin

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Structured PICO

Population

Wistar rats (n=66)

Intervention

Doxorubicin (DOX) intraperitoneal injections: either a single dose (4 mg/kg body weight) or multiple doses (4 injections of 4 mg/kg body weight/week)

Comparator

Baseline (before injection)

Outcome

Cardiac total antioxidant performance (TAP), DNA damage (strand breaks and oxidized pyrimidines), and morphology (cardiac disarrangement, necrosis)surrogate

Acute doxorubicin cardiotoxicity is associated with oxidative damage, whereas chronic toxicity from multiple doses may involve different mechanisms due to increased resistance to oxidative stress.

Discussion

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Implication

Supports distinct acute vs chronic DOX mechanisms in animals; hypothesis-generating and leaves open clinical translation.

Cite This Study

Segredo et al. (2013) studied this question.

synapsesocial.com/papers/6a82aa1792c19701ea21e344 https://doi.org/10.1177/0960327113512342

View Full Paper

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Oxidative stress on cardiotoxicity after treatment with single and multiple doses of doxorubicin

Structured PICO

Discussion

Implication

Cite This Study

Oxidative stress on cardiotoxicity after treatment with single and multiple doses of doxorubicin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider