Why the study?
Does aliskiren administration affect the quantification of active renin by different immunoradiometric assays compared to valsartan in healthy male subjects?
Does aliskiren administration affect the quantification of active renin by different immunoradiometric assays compared to valsartan in healthy male subjects?
Renin inhibitors like aliskiren can cause conformational changes in prorenin that interfere with monoclonal antibody recognition in commercial assays, leading to overestimation of active renin.
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Assay-specific bias after aliskiren warrants caution in renin interpretation; challenges interchangeability of commercial assays in trials and practice.
Ménard et al. (2006) studied this question.
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