Population
Rat model of cardiac pressure-overload hypertrophy induced by aortic constriction
Design
Preclinical
Follow-up
3 to 60 days
Authors
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Early RAS activation in animal pressure overload precedes sympathetic changes; hypothesis-generating and should not alter clinical practice.
Activation of the renin-angiotensin system is an early response to pressure overload that precedes sympathetic activation in the development of cardiac hypertrophy.
Akers et al. (2000) studied this question.
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