Population
Preclinical models (including transgenic mice and cultured neonatal cardiomyocytes) of cardiac hypertrophy.
Design
Review
Authors
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Supports Gαq as research target in hypertrophy; leaves open clinical translation amid redundant pathways.
This review highlights the critical role of the Gαq/PLC βI/PKC signal transduction pathway in mediating cardiac hypertrophy and contractile dysfunction, providing insights into the molecular pathogenesis of heart failure.
Thunder Jalili (1999) studied this question.
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