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An assay is described that permits the study of the kinetics of DNA cross-link precursor formation, the kinetics of cross-formation, and the kinetics of the repair of these DNA cross-link precursor lesions, at physiological pH values. Due to the relatively rapid nature of these processes existing assays are not suited to the study of these processes. Data obtained using this assay can be used to optimize the design of certain classes of anticancer drugs.
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Philip G. Penketh (2024) studied this question.
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