What question did this study set out to answer?

To establish genetically accurate preclinical mouse models of lung squamous cell carcinoma and determine whether SOX2 functions as an oncogenic driver across different cells of origin.

October 1, 2016Cancer CellOpen Access

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

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Authors

GFGiustina FeroneUniversity of Naples Federico II JSJi‐Ying SongHoward Hughes Medical Institute RBRajith BhaskaranCharles University

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Implication

Preclinical mouse model demonstrates that SOX2 overexpression with Pten and Cdkn2ab loss drives lung squamous cell carcinoma across lung cell types, highlighting a master oncogenic switch.

Key Points

To establish genetically accurate preclinical mouse models of lung squamous cell carcinoma and determine whether SOX2 functions as an oncogenic driver across different cells of origin.
Engineered mouse models carrying combinations of genetic lesions commonly observed in human lung squamous cell carcinoma, including SOX2 or FGFR1 overexpression alongside Cdkn2ab and Pten deletion.
Targeted genetic alterations selectively to tracheobronchial basal cells, Club cells, or alveolar type 2 (AT2) cells to evaluate cell-of-origin effects on tumor formation and anatomical site.
SOX2 overexpression combined with Cdkn2ab and Pten loss in tracheobronchial basal cells drove the formation of squamous cell carcinomas closely mirroring human disease, whereas FGFR1 overexpression failed to do so.
Targeting the Sox2;Pten;Cdkn2ab alteration profile to Club or alveolar type 2 cells successfully generated squamous carcinomas exhibiting a distinctly peripheral lung localization.

Cite This Study

Ferone et al. (2016) studied this question.

synapsesocial.com/papers/6a82aba49192075d3cd4aeb3 https://doi.org/10.1016/j.ccell.2016.09.001

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Implication

Preclinical mouse model demonstrates that SOX2 overexpression with Pten and Cdkn2ab loss drives lung squamous cell carcinoma across lung cell types, highlighting a master oncogenic switch.

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

Discussion

Member takes

Implication

Key Points

Cite This Study

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

Discussion

Member takes

Implication

Key Points

Cite This Study

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