What question did this study set out to answer?

To evaluate whether serum and tumor tissue copper-to-zinc ratios can effectively differentiate malignant from benign ovarian tumors in women presenting with a pelvic mass.

January 1, 1986Clinical ChemistryOpen Access

Use of the serum copper/zinc ratio in the differential diagnosis of ovarian malignancy.

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Authors

ALAbraham LightmanTechnion – Israel Institute of Technology JBJoseph M. BrandesUniversity of Kansas NBN Binur

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Implication

Diagnostic study demonstrates elevated serum copper-to-zinc ratios in women with malignant ovarian tumors, highlighting its potential utility in differential diagnosis.

Key Points

To evaluate whether serum and tumor tissue copper-to-zinc ratios can effectively differentiate malignant from benign ovarian tumors in women presenting with a pelvic mass.
Measured copper and zinc concentrations in serum (n = 82) and tumor tissue (n = 41) from women admitted with a palpable pelvic mass and suspected ovarian tumor.
Compared trace metal levels and ratios between patients confirmed to have malignant ovarian tumors (n = 40) and those with benign masses (n = 42).
Mean serum copper/zinc ratio was significantly higher in the malignant group at 2.30 (SD 0.41) compared with 1.43 (SD 0.22) in the benign group (p < 0.001).
Tissue copper/zinc ratio was also significantly higher in malignant tumors at 0.158 (SD 0.065) compared with benign tissue at 0.093 (SD 0.04; p < 0.001).

Cite This Study

Lightman et al. (1986) studied this question.

synapsesocial.com/papers/6a82abab9192075d3cd4aebf https://doi.org/10.1093/clinchem/32.1.101

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Implication

Diagnostic study demonstrates elevated serum copper-to-zinc ratios in women with malignant ovarian tumors, highlighting its potential utility in differential diagnosis.

Use of the serum copper/zinc ratio in the differential diagnosis of ovarian malignancy.

Discussion

Member takes

Implication

Key Points

Cite This Study

Use of the serum copper/zinc ratio in the differential diagnosis of ovarian malignancy.

Discussion

Member takes

Implication

Key Points

Cite This Study

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