Why the study?
Carotid artery stenosis alters circle of Willis blood flow and may contribute to aneurysm formation, raising the need to study its hemodynamic effects on brain vessel aneurysm development.
Does the degree of carotid artery stenosis and circle of Willis anomalies affect wall shear stress and mass blood flows in communicating arteries?
Population
45 models of the circle of Willis and carotid arteries based on computed angiography data
Comparison
Various degrees of carotid artery stenosis and anatomical variants of the circle of Willis
Design
Biomechanical numerical modeling study
Authors
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Certain stenosis-Willis combinations may heighten aneurysm risk; leaves open human translation of modeling results.
Does the degree of carotid artery stenosis and circle of Willis anomalies affect wall shear stress and mass blood flows in communicating arteries?
Numerical modeling demonstrates that specific combinations of carotid artery stenosis and circle of Willis anomalies significantly alter hemodynamics, potentially increasing the risk of cerebral aneurysm formation.
Dol et al. (2021) studied this question.
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