Why the study?
Does ROS stress alter hERG1 potassium channel activity in HEK293 cells?
Population
HEK293 cells expressing hERG1 and mutants thereof
Design
Preclinical
Authors
Loading...
May link Cys723 oxidation to arrhythmia risk under oxidative stress; hypothesis-generating, requires validation in native tissue.
Does ROS stress alter hERG1 potassium channel activity in HEK293 cells?
Cysteine 723 in the C-linker segment of hERG1 channels is critical for ROS-induced oxidative inhibition, providing a molecular mechanism for potential arrhythmia under oxidative stress conditions.
Kolbe et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: