December 30, 2009Cardiovascular ResearchOpen Access

Loss-of-function mutation of the SCN3B-encoded sodium channel 3 subunit associated with a case of idiopathic ventricular fibrillation

View Full Paper

Ask AI

Bookmark

Population

A 20-year-old male with idiopathic ventricular fibrillation following witnessed collapse and defibrillation…

Comparison

Identification and in vitro functional… vs Wild-type (WT) Navbeta3.

Design

Case_report

Authors

CVCarmen R. ValdiviaUniversity of Wisconsin–Madison AMArgelia Medeiros‐DomingoElectrophysiology BYBing YeShanghai Jiao Tong University

Discussion

Member takes

Implication

Suggests SCN3B loss-of-function may underlie idiopathic VF; hypothesis-generating and requires validation before any clinical adoption.

Structured PICO

Population

A 20-year-old male with idiopathic ventricular fibrillation (IVF) following witnessed collapse and defibrillation, with structurally normal heart and ECG exhibiting epsilon waves; and in vitro models (HEK-293 and COS cells).

Intervention

Identification and in vitro functional characterization of the Navbeta3-V54G missense mutation.

Comparator

Wild-type (WT) Navbeta3.

Outcome

Effect of Navbeta3-V54G mutation on peak sodium current, inactivation, and channel trafficking to the plasma membrane in vitro.surrogate

This study provides molecular and cellular evidence that loss-of-function mutations in the SCN3B-encoded Navbeta3 subunit can cause idiopathic ventricular fibrillation.

Cite This Study

Valdivia et al. (2009) studied this question.

synapsesocial.com/papers/6a82b28ed88fdfcf4fa0c801 https://doi.org/10.1093/cvr/cvp417

Topics

Cardiac device therapy

View Full Paper

Ask AI

Bookmark

Loss-of-function mutation of the SCN3B-encoded sodium channel 3 subunit associated with a case of idiopathic ventricular fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Loss-of-function mutation of the SCN3B-encoded sodium channel 3 subunit associated with a case of idiopathic ventricular fibrillation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider