Assessment of Interferon INF- y and Vitamin D levels among Chronic Hepatitis B Virus Patients in Khartoum- Sudan

Introduction: In Sudan Hepatitis B virus, (HBV) infection is the most common cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) worldwide, interferon γ INF γ is significantly associated with chronic hepatitis B virus (HBV) infection. However, the relationship between low serum vitamin D levels and HBV chronicity is unknown. Objective: The aim of this study was to assess (INF γ) levels and the pattern of vitamin D levels, in patients with chronic HBV infection compared with healthy individuals. Methodology: 90 chronically HBV-infected, were randomly selected in the present study. A serum vitamin D level measured by using Electro-chemiluminescence binding assay (ECLIA). The INF γ and HBsAg serum level were measured by using an in vitro diagnostic (ELISA). Results: A total of 180 individuals were selected in the present study, 90 of them were case study of chronic hepatitis B virus infection, and 90 were case control healthy individual. The mean serum level of 25(OH) D was for case was 11.63 ng/mL. Out of the 180 participant, 93 (53.8%) were female and 87(46.2%) were male. Vitamin D and INF γ were significantly decreased in case group in comparison with the control (p value 0.002). Conclusions: Vitamin D deficiency and interferon γ are significantly associated with chronic HBV infection.