Why the study?
This study aimed to evaluate prognosis after minor acute ischemic stroke or transient ischemic attack using definitions of subsequent stroke aligned with recent clinical trials.
Patients with minor acute ischemic stroke or high-risk TIA have a substantial risk of subsequent stroke or death, particularly in the first month and among those with large artery atherosclerosis.
High early event rates after minor AIS or high-risk TIA warrant close monitoring; leaves open optimal prevention for large-artery atherosclerosis.
This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.
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Lee et al. (2022) studied this question.
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