Key points are not available for this paper at this time.
Design
Review
Caution against monotherapy for hypertension; leaves open combination strategies for prospective trials.
Natriuretic peptides are produced in the brain, heart and vasculature, and cause vasodilation, sodium excretion, and diuresis. Recent advances indicate that they play important roles in blood-pressure homeostasis, both in normal and in pathophysiological conditions. Although therapeutic interventions which elevate plasma natriuretic peptide levels do not have great antihypertensive efficacy, animal studies suggest that they may be useful in combination treatment strategies.
No takes yet. Share an insight, caveat, or question.
Prins et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: