Why the study?
Does irbesartan and/or simvastatin alleviate atrial fibrosis via the PDGF/Rac1/NF-κB axis in a TAC rat model?
Does irbesartan and/or simvastatin alleviate atrial fibrosis via the PDGF/Rac1/NF-κB axis in a TAC rat model?
Irbesartan and simvastatin, alone or in combination, can alleviate atrial fibrosis by regulating the PDGF/Rac1/NF-κB axis in a preclinical model.
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Hypothesis-generating in TAC rats; leaves open any clinical role for irbesartan-simvastatin in human atrial fibrosis.
Yang et al. (2013) studied this question.
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