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January 1, 2002Internal MedicineOpen Access

Microvascular Angina Accompanied by Epicardial Coronary Artery Spasm.

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Why the study?

Does the combined use of amlodipine and high-dose nicorandil improve symptoms in a patient with microvascular angina and epicardial coronary artery spasm?

Population

A 54-year-old woman with microvascular angina accompanied by epicardial coronary artery spasm, presenting…

Design

Case_report

Authors

MHMasashi HorimotoHokkaido University of ScienceHSHitoshi SakuragiNippon Soken (Japan)TTTakashi TakenakaNEC (Japan)

Discussion

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Implication

May support refractory mixed angina cases; hypothesis-generating, requires randomized confirmation before practice change.

Structured PICO

Does the combined use of amlodipine and high-dose nicorandil improve symptoms in a patient with microvascular angina and epicardial coronary artery spasm?

P
Population
A 54-year-old woman with microvascular angina accompanied by epicardial coronary artery spasm, presenting with anginal pain at rest and during exercise (n=1).
I
Intervention
Combined use of amlodipine and high-dose nicorandil
O
Outcome
Relief of angina symptomspatient reported

Combined therapy with amlodipine and high-dose nicorandil may be effective for treating angina in patients with concurrent microvascular angina and epicardial coronary artery spasm.

Cite This Study

Horimoto et al. (2002) studied this question.

synapsesocial.com/papers/6a82b4f6db35670cc923b660https://doi.org/10.2169/internalmedicine.41.216
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced coronary dilatory capacity and ultrastructural changes of the myocardium in patients with angina pectoris but normal coronary arteriograms.1981 · 441 citations
  2. 2Left ventricular dysfunction in patients with angina pectoris, normal epicardial coronary arteries, and abnormal vasodilator reserve.1985 · 238 citations
  3. 3Is coronary flow reserve in response to papaverine really normal in syndrome X?1994 · 70 citations
  4. 4Acute effects of nitrates on exercise testing in patients with syndrome X. Clinical and pathophysiological implications.1994 · 92 citations