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The effects of thyrocalcitonin (TCT) on calcium influx, cellular calcium concentration and calcium efflux were measured in kidney cells. Thyrocalcitonin increased the calcium concentration in the cell but decreased the calcium turnover as measured by the per cent calcium exchanged. Furthermore, TCT significantly depressed calcium efflux within 10 min and a maximum 40% inhibition was obtained at 30 min. These results suggest that TCT inhibits the extrusion of calcium, thereby increasing its cellular concentration. (Endocrinology85: 194, 1969)
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A. B. Borle (1969) studied this question.
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