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More than ten different proto-oncogenes have been identified in the genome of Drosophila melanogaster. Their structural characterizations shows a high degree of conservation compared with the corresponding genes in vertebrates, and provides interesting clues to the evolution of proto-oncogenes. During Drosophila development proto-oncogenes are expressed in proliferating cells as well as in several differentiated tissues, suggesting that they serve pleiotropic functions.
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Ben‐Zion Shilo (1987) studied this question.
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