June 1, 1983British Journal of PharmacologyOpen Access

Cyclic adenosine 3′,5′‐monophosphate and β‐effects in rat isolated superior cervical ganglia

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Population

Rat isolated superior cervical ganglia

Comparison

Isoprenaline and other pharmacological agents vs Control conditions

Design

Preclinical

Authors

DBDavid A. BrownGalveston College PDPhilip M. DunnThe Royal Free Hospital

Discussion

Member takes

Implication

Suggests cAMP-independent isoprenaline effects in sympathetic ganglia; leaves open alternative pathways for cardiovascular autonomic research.

Structured PICO

Population

Rat isolated superior cervical ganglia

Intervention

Isoprenaline (0.01-1 microM) and other pharmacological agents (salbutamol, butoxamine, practolol, SQ 22,536, dibutyryl cyclic AMP, phosphodiesterase inhibitors)

Comparator

Control conditions

Outcome

Cyclic AMP levels and electrical responses (ganglion depolarization and facilitation of submaximal transmission)surrogate

The study demonstrates that isoprenaline-induced ganglion depolarization and facilitation of submaximal transmission in rat isolated superior cervical ganglia are unlikely to be mediated by cyclic AMP.

Cite This Study

Brown et al. (1983) studied this question.

synapsesocial.com/papers/6a82b613ca0a238f9c75b046 https://doi.org/10.1111/j.1476-5381.1983.tb11017.x

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Implication

Suggests cAMP-independent isoprenaline effects in sympathetic ganglia; leaves open alternative pathways for cardiovascular autonomic research.