Why the study?
Does omental adipose tissue gene expression differ between morbidly obese women with and without PCOS?
Population
15 morbidly obese women undergoing bariatric surgery
Comparison
Omental fat biopsy during bariatric surgery vs Nonhyperandrogenic morbidly obese women…
Design
Case-control
Authors
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Supports visceral adipose dysfunction in PCOS pathogenesis; hypothesis-generating and should not yet change practice.
Does omental adipose tissue gene expression differ between morbidly obese women with and without PCOS?
Visceral adipose tissue in PCOS patients shows differential expression of multiple genes related to insulin signaling, inflammation, and lipid metabolism, suggesting a broader role of abdominal obesity in PCOS pathogenesis.
Cortón et al. (2006) studied this question.
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