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April 1, 1969Archives of Surgery

Surgery of the Colon

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Why the study?

Does the use of chemotherapeutic agents and antibiotics reduce mortality in patients undergoing colon and rectal surgery?

Population

Patients undergoing colon and rectal surgery for neoplastic and inflammatory diseases

Comparison

Chemotherapeutic agents and antibiotics vs Historical management without these agents

Design

Review

Authors

OBOliver H. BeahrsAmerican Cancer Society

Discussion

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Overview

May support perioperative antibiotics in colorectal surgery; leaves open optimal modern regimens amid resistance.

Structured PICO

Does the use of chemotherapeutic agents and antibiotics reduce mortality in patients undergoing colon and rectal surgery?

P
Population
Patients undergoing colon and rectal surgery for neoplastic and inflammatory diseases
I
Intervention
Chemotherapeutic agents (sulfonamides) and antibiotics (phthalylsulfathiazole and neomycin)
C
Comparator
Historical management without these agents (prior to the late 1930s)
O
Outcome
Mortalityhard clinical

The historical introduction of sulfonamides and antibiotics drastically reduced mortality in colon and rectal surgery.

Cite This Study

Oliver H. Beahrs (1969) studied this question.

synapsesocial.com/papers/6a82b6b9d88fdfcf4fa0c88bhttps://doi.org/10.1001/archsurg.1969.01340100112015
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CRITICAL ANALYSIS OF INTESTINAL ANTISEPSIS1957 · 50 citations
  2. 2INTESTINAL ANTISEPSIS IN SURGERY1953 · 63 citations