Association among PlA1/A2 gene polymorphism, laboratory aspirin resistance and clinical outcomes in patients with coronary artery disease: An updated meta-analysis

Figures

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  Figure 1. Flowchart of the study selection.

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  Figure 2. Association between PlA1/A2 polymorphism and laboratory aspirin resistance. The position of the blue squares corresponds to the odds ratio (OR) per study and the horizontal black line to the 95% confidence intervals (CI). The size of the square is proportional to the relative weight of that study w(%) to compute the overall OR (black diamond). The width of the diamond represents the 95% CI of the overall OR. If a 95% CI spans one (indicated by the black vertical solid line), this study has found no significant difference in the incidence of aspirin resistance (AR) between patients carrying the PlA1 and PlA2 alleles. This meta-analysis shows no significant change in the incidence of AR of patients carrying the PlA2 allele over those carrying PlA1 allele. The overall OR is 0.94 (P = 0.74). Note that the p-value mentioned here is the p-value for Z test.

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  Figure 3. Association between PlA1/A2 polymorphism and clinical outcomes. Symbols and conventions are the same as in Fig. 2. This meta-analysis shows no significant change in the incidences of death, MI or TVR of patients carrying the PlA2 allele over those carrying PlA1 allele. The overall ORs of death, MI and TVR are 0.51(P = 0.28), 1.13 (P = 0.51) and 0.89 (P = 0.72) respectively. Note that the p-values mentioned here are the p-values for Z test. CI, confidence interval; MI, myocardial infarction; TVR, target vessel revascularization.

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  Figure 4. Association between laboratory aspirin resistance and clinical outcomes. Symbols and conventions are the same as in Fig. 2. This meta-analysis shows significant overall increase in the incidences of death and TVR of patients with AR over those without AR, while no significant change in the incidences of MI or stroke. The overall ORs in death, MI, stroke and TVR are 2.42 (P < 0.00001), 0.95 (P = 0.79), 1.64 (P = 0.46) and 2.2 (P = 0.01) respectively. Note that the p-values mentioned here are the p-values for Z test. CI, confidence interval; ASA, aspirin; MI, myocardial infarction; TVR, target vessel revascularization.