Why the study?
Is the Glycoprotein IIIA Gene PlA2 allele associated with an increased risk of acute coronary syndrome and aspirin resistance?
Is the Glycoprotein IIIA Gene PlA2 allele associated with an increased risk of acute coronary syndrome and aspirin resistance?
The PlA2 allele is associated with an increased risk of acute coronary syndrome and an inadequate platelet response to aspirin therapy, suggesting a potential need for alternative antiplatelet strategies in these patients.
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PlA2 carriage was associated with higher ACS risk and aspirin resistance; hypothesis-generating for genotyping-guided therapy pending prospective trials.
Papp et al. (2005) studied this question.
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