The Morphology and Pathogenesis of Cardiac Fibrosis of the Liver

Article1 April 1952THE MORPHOLOGY AND PATHOGENESIS OF CARDIAC FIBROSIS OF THE LIVERELI MOSCHCOWITZELI MOSCHCOWITZAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-4-933 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe term "fibrosis" was purposely chosen instead of the conventional "cirrhosis" because the latter has too many connotations. Observers have displayed a wide diversity of opinion concerning the finer morphology and pathogenesis of the hepatic lesions associated with cardiac disease. There are a number of reasons for this: first, because the lesions were studied from a static rather than a biologic viewpoint; second, because the topography of the lesions was not controlled by serial section; third, because the genesis of the fibrosis was divorced from the vasculature of the liver; and fourth, because the significance of certain phases of...Bibliography1. Moschcowitz E: The pathogenesis of splenomegaly in hypertension of the portal circulation; "congestive splenomegaly," Medicine 27: 187, 1948. CrossrefMedlineGoogle Scholar2. Pick E: Über chronische unter den Bilde der Leber Cirrhose vorlaegende Pericarditis, Ztschr. f. klin. Med. 29: 385, 1896. Google Scholar3. Moschcowitz E: Phlebosclerosis of the hepatic veins, Anniversary volume in honor of Dr. E. Libman, 1932, International Press. Google Scholar4. Moschcowitz E: The association of capillary sclerosis with arteriosclerosis and phlebosclerosis, its pathogenesis and clinical significance, Ann. Int. Med. 30: 1156, 1949. LinkGoogle Scholar5. KatzinWallerBlumgart HMJVHL: "Cardiac cirrhosis" of the liver, Arch. Int. Med. 64: 457, 1939. CrossrefGoogle Scholar6. KoletzkyBarnebee SJH: "Cardiac" or congestive cirrhosis, Am. J. M. Sc., 207: 421, 1944. CrossrefGoogle Scholar7. Gerlach W: Die Kreislaufstörungen der Leber, Handb. d. spez. path. Anat. u. Histol. (Teil I) 5: 71-131, 1930. Google Scholar8. LambertAllison RABR: Types of lesions in chronic congestion of the liver, Bull. Johns Hopkins Hosp. 26: 350, 1916. Google Scholar9. Willius FA: The effects of protracted and recurrent congestive heart failure on the liver, Virginia M. Monthly 66: 1-5 (Jan.) 1939. Google Scholar10. Herxheimer G: Zur Pathologie der Gitterfasern der Leber, Beitr. z. path. Anat. u. z. allg. Path. 43: 284, 1908. Google Scholar11. Moschcowitz E: Relation of lymphocytic infiltration of inflammatory origin to angiogenesis, Arch. Path. 49: 247, 1950. Google Scholar12. Mall EP: A study of the structural unit of the liver, Am. J. Anat. 5: 227, 1906. CrossrefGoogle Scholar13. Piery M: Pathogenie de la cirrhose cardiaque: Stase sanguine et sclerose du foie, Arch. gén. de méd. 2: 582, 714, 1900. Google Scholar14. Eisenmenger V: Über die Stauungscirrhose der Leber, Ztschr. f. Heilk. (Path. Abt.) 23: 171, 1902. Google Scholar15. Bellis CJ: The portal venous pressure in man, Proc. Soc. Exper. Biol. and Med. 50: 258, 1942. CrossrefGoogle Scholar16. Mallory FB: Chronic passive congestion of the liver, J. M. Research 6: 264, 1901. MedlineGoogle Scholar17. ZimmermanHillsman HMJA: Chronic passive congestion of the liver, an experimental study, Arch. Path. 9: 1154, 1930. Google Scholar18. Burton-Opitz R: The vascularity of the liver. I. The flow of blood in the hepatic artery, Quart. J. Exper. Physiol. 3: 297, 1910. CrossrefGoogle Scholar19. MacLeodPearce JJRG: The outflow of blood from the liver as affected by variations in the condition of the portal vein and hepatic artery, Am. J. Physiol. 35: 87, 1914. CrossrefGoogle Scholar20. Thoma R: Ueber die Strömung des Blutes in der Gefässbahn und die Spannung der Gefässwand, ihre Bedeutung für das normale Wachstum, für die Blutstillung und für die Angiosklerose, Beitr. z. path. Anat. u. z. allg. Path. 66: 377, 1920. Google Scholar21. Moschcowitz E: The pathogenesis of Laennec cirrhosis, Arch. Path. 45: 187, 1948. Google Scholar22. WakimMann KGFC: The intrahepatic circulation of blood, Anat. Rec. 82: 233, 1942. CrossrefGoogle Scholar23. EllenbergOsserman MK: Paper to be shortly published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication August 10, 1951.From the Laboratories, Department of Pathology, The Mount Sinai Hospital, New York, N. Y. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insightsChronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forcesCentrilobular and perisinusoidal fibrosis in experimental congestive liver in the ratRole of thrombosis in the pathogenesis of congestive hepatic fibrosis (cardiac cirrhosis)Alcoholic liver disease: Information in search of knowledge?Histopathological Studies on Lesions of the Liver and Blood Vessels due to Congestive Heart FailureHistology of the intestinal peritoneum in patients with cirrhosis of the liver and ascitesPlasma Protein Electrophoresis During a Three-Hour Cardio-Pulmonary Bypass in DogsThe Liver in Congestive Heart FailureChanges in the hepatic vascular pattern that follow ligation of the common bile duct in rabbitsACINAR UNITS AND THE PATHOPHYSIOLOGY OF THE LIVERPROTEIN-LOSING GASTROENTEROPATHY IN CONGESTIVE HEART-FAILUREBetrachtungen zur Pathophysiologie der LeberstrukturChiari's disease and the Budd-Chiari syndromePortal HypertensionCase 46061Die pathologische Anatomie der HerzinsuffizienzREFERENCESThe liver in congestive heart failurePathogenesis of hypertension of the portal circulationSIMPLE PULMONARY STENOSIS PULMONARY VALVULAR STENOSIS WITH A CLOSED VENTRICULAR SEPTUMLiver disease—Morphologic considerationsCase 39432Cirrhosis of the Liver: Natural History of a DiseaseCase 38481 1 April 1952Volume 36, Issue 4Page: 933-955KeywordsBiologicsCirrhosisFibrosisHeart diseasesLesionsLiver fibrosisPathogenesis ePublished: 1 December 2008 Issue Published: 1 April 1952 Copyright & PermissionsCopyright, 1952, by The American College of PhysiciansPDF downloadLoading ...