Key result
The hypothesis that cardiac muscle hypertrophies due to increased work cannot readily explain certain phenomena associated with cardiac hypertrophy.
This historical article discusses the theoretical and observed relationships between cardiac hypertrophy, coronary arteriosclerosis, and congestive heart failure.
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Questions work hypothesis for hypertrophy; leaves open mechanisms linking it to arteriosclerosis and failure.
David Davis (1937) conducted a review in Cardiac hypertrophy. Increased cardiac work was evaluated. The hypothesis that cardiac muscle hypertrophies due to increased work cannot readily explain certain phenomena associated with cardiac hypertrophy.
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