Answers are grounded in this paper and cite their sources.
Almost one hindered steps were necessary to synthesize the FGHIJ ring framework 1 of brevetoxin A in its naturally occurring enantiomeric form from the readily accessible carbohydrates D-mannose, 2-deoxy-D-ribose, and tri-O-acetyl-D-glucal. Despite the large number of steps the synthesis is highly convergent, which makes the efficiency even more impressive.
No takes yet. Share an insight, caveat, or question.
Nicolaou et al. (1991) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: