Why the study?
Do MDA5 and MAVS mediate type I interferon responses and survival in mice infected with Coxsackie B virus?
Do MDA5 and MAVS mediate type I interferon responses and survival in mice infected with Coxsackie B virus?
MDA5 and MAVS are critical for type I interferon production and survival during Coxsackie B virus infection in mice.
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MAVS/MDA5 loss precipitates lethal CVB outcomes in mice; leaves open their role as therapeutic targets in human enteroviral disease.
Wang et al. (2009) studied this question.
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