Why the study?
Do chemiluminescence and PCR improve diagnostic accuracy for Chagas' disease compared to conventional serological tests?
Population
414 sera for the diagnosis of Chagas' disease
Comparison
Chemiluminescence and PCR vs Conventional serological tests
Design
Cross-sectional
Authors
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Retains conventional serology as adequate for Chagas diagnosis; leaves open whether chemiluminescence or PCR merit further validation.
Do chemiluminescence and PCR improve diagnostic accuracy for Chagas' disease compared to conventional serological tests?
Conventional serological reactions remain adequate for diagnosing Chagas' disease, as PCR showed very low sensitivity and chemiluminescence had lower specificity.
Duarte et al. (2006) studied this question.
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