Key result
The trans-sialidase inhibition assay detected 60% of conventionally seronegative Chagas' samples as positive and discriminated chagasic from idiopathic cardiopathy without cross-reaction.
Why the study?
Does the trans-sialidase inhibition assay improve diagnostic accuracy for Chagas' disease compared to conventional serology?
Does the trans-sialidase inhibition assay improve diagnostic accuracy for Chagas' disease compared to conventional serology?
The trans-sialidase inhibition assay is a highly sensitive and specific diagnostic test that can resolve borderline cases and identify Chagas' disease in patients negative by conventional serology.
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May aid Chagas diagnosis in serologically equivocal cases; leaves open prospective validation before clinical adoption.
Buchovsky et al. (2001) studied this question. The trans-sialidase inhibition assay detected 60% of conventionally seronegative Chagas' samples as positive and discriminated chagasic from idiopathic cardiopathy without cross-reaction.
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