October 1, 1988Journal of Parasitology

A New Method for Diagnosis of Chagas' Disease: Diffusion-in-Gel Enzyme-Linked Immunosorbent Assay

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Why the study?

Does DIG-ELISA accurately detect antibodies to T. cruzi compared to the indirect hemagglutination test?

Structured PICO

Does DIG-ELISA accurately detect antibodies to T. cruzi compared to the indirect hemagglutination test?

Population

Sera from individuals with past or present exposure to T. cruzi, normal human sera, and sera from individuals with toxoplasmosis or cutaneous leishmaniasis

Intervention

Diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA) using formalinized epimastigotes as antigen

Comparator

Indirect hemagglutination test

Outcome

Diagnostic accuracy (reaction zone diameters and correlation with indirect hemagglutination test)surrogate

DIG-ELISA is a promising and accurate serological test for measuring antibodies to T. cruzi, the causative agent of Chagas' disease.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

DIG-ELISA shows high specificity for T. cruzi antibodies; leaves open prospective validation before clinical adoption.

Cite This Study

Castilla et al. (1988) studied this question.

synapsesocial.com/papers/6a894b92a90c2f4c44fb9009 https://doi.org/10.2307/3282258

View Full Paper

Ask AI

Bookmark

A New Method for Diagnosis of Chagas' Disease: Diffusion-in-Gel Enzyme-Linked Immunosorbent Assay

Structured PICO

Discussion

Implication

Cite This Study

A New Method for Diagnosis of Chagas' Disease: Diffusion-in-Gel Enzyme-Linked Immunosorbent Assay

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider