Population
Porcine ventricular trabeculae permeabilised with Triton X-100 and intact rat papillary muscle
Comparison
BA 41899 and its enantiomer CGP 48506 vs Absence of the agent
Design
Preclinical
Authors
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Alters myofilament Ca²⁺ sensitivity and force in vitro; leaves open translation to intact hearts or inotrope development.
The novel inotropic agent CGP 48506 alters cardiac force production primarily through Ca2+-independent mechanisms.
Samuel Palmer (1996) studied this question.
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