Sickle-Cell Anemia: The Known and the Unknown

Editorial Notes1 July 1972Sickle-Cell Anemia: The Known and the UnknownSAMUEL CHARACHE, M.D., F.A.C.P.SAMUEL CHARACHE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-1-148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSickle-cell anemia has become a topic of intense public interest; newspaper columnists, college students, baseball players, and Marcus Welby have devoted attention to it. The Congress has also paid attention, and it seems possible that more than 100 million dollars will be appropriated to "fight" this disease. Contrary to public opinion, research in this area has not been lacking in the past, although the anticipated influx of money has awakened much new interest. We now understand more about the pathogenesis of the illness, from molecule to man, than we do about that of almost any other disease (1). Like many...References1. BOYER S, CHARACHE S, and CONLEY C: Sickle cell research. Nature (Lond) 231:477, 1971 CrossrefMedlineGoogle Scholar2. RANNEY H: Sickle cell disease. Blood 39:433-439, 1972 CrossrefMedlineGoogle Scholar3. BARCLAY G, HUNTSMAN R, and ROBB A: Population screening of young children for sickle cell anaemia in Zambia. Trans R Soc Trop Med Hyg 64:733-739, 1970 CrossrefMedlineGoogle Scholar4. BELL R and GELFAND M: Sickle cell disease in Rhodesia. J Trop Med Hyg 74:148-153, 1971 MedlineGoogle Scholar5. KONOTEY-AHULU F: Computer assisted analysis of data on 1,697 patients attending the sickle cell/haemoglobinopathy clinic of Korle-Bu Teaching Hospital, Accra, Ghana. Clinical features. I. Sex, genotype, age, rheumatism and dactylitis frequencies. Ghana Med J 10:241-260, 1971 Google Scholar6. WINTROBE M: Clinical Hematology, 2nd ed Philadelphia, Lea and Febiger, 1946, p. 515 Google Scholar7. WINTROBE M: Clinical Hematology, 6th ed. Philadelphia, Lea & Febiger, 1967, p. 704 Google Scholar8. CHARACHE S and RICHARDSON S: Prolonged survival of a patient with sickle cell anemia. Arch Intern Med 113:844-849, 1964 CrossrefMedlineGoogle Scholar9. DIGGS L and FLOWERS E: Sickle cell anemia in the home environment. Clin Pediatr 10:697-700, 1971 CrossrefMedlineGoogle Scholar10. SERJEANT G: The clinical features in adults with sickle cell anaemia in Jamaica. West Indian Med J 19:1-8, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SAMUEL CHARACHE, M.D., F.A.C.P.Affiliations: Department of Medicine Johns Hopkins University School of Medicine Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNatural History of Sickle Cell Anemia in Saudi Arabs A Study of 270 SubjectsRICHARD P. PERRINE, M.D., MARCUS E. PEMBREY, M.B., M.R.C.P. (U.K.), PETER JOHN, M.B., SUSAN PERRINE, M.D., FERIAL SHOUP, R.N.Cholelithiasis in sickle cell anemia in a caucasian population 1 July 1972Volume 77, Issue 1Page: 148-149KeywordsAnemiaPathogenesis ePublished: 1 December 2008 Issue Published: 1 July 1972 PDF downloadLoading ...