A High Incidence of Cough Associated With Combination Therapy of Hypertension With Isradipine and Usinopril in Chinese Subjects

SUMMARY The efficacy and tolerability of combination therapy using Lisinopril (5 – 20 mg om) and Isradipine (1.25mg – 2.50 mg bd) was assessed in 29/50 Chinese subjects, whose blood pressures were not controlled on Isradipine alone. The addition of Lisinopril produced approximately two‐fold reductions in blood pressure compared to Isradipine alone, increasing the responder rate of the original cohort of 50 subjects by 18% and normalization rate by 32%. No significant changes in haematological or biochemical parameters, CXR or ECG, were observed. However, use of Lisinopril in our subjects was associated with a high incidence of cough (48%), possibly limiting its use in this population.