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June 1, 1991AnesthesiologyOpen Access

Alteration of Left Ventricular Diastolic Function by Desflurane, Isoflurane, and Halothane in the Chronically Instrumented Dog with Autonomie Nervous System Blockade

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Population

11 chronically instrumented dogs with autonomic nervous system blockade

Comparison

Desflurane, isoflurane, or halothane at 1.0 and… vs Conscious state (control)

Design

Preclinical

Follow-up

30 min equilibration per dose

Authors

PPPaul S. PagelStructural Heart DiseaseJKJohn P. KampineElectrophysiologyWSWilliam T. SchmelingMarquette University

Discussion

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Implication

Caution against extrapolating canine diastolic effects to patients; leaves open whether halothane uniquely impairs compliance in humans.

Structured PICO

P
Population
11 chronically instrumented dogs with autonomic nervous system blockade
I
Intervention
Desflurane, isoflurane, or halothane at 1.0 and 1.5 MAC
C
Comparator
Conscious state (control)
O
Outcome
Left ventricular diastolic function indices (isovolumetric relaxation time constants, chamber stiffness, myocardial stiffness)surrogate

Desflurane, isoflurane, and halothane similarly prolong isovolumetric relaxation in dogs, while halothane uniquely decreases ventricular compliance during passive filling.

Limitations

  • Effects of volatile anesthetics on systolic function could not be entirely excluded from the analysis

Cite This Study

Pagel et al. (1991) studied this question.

synapsesocial.com/papers/6a82bb6ffb68d755121c23cfhttps://doi.org/10.1097/00000542-199106000-00019
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Desflurane and Isoflurane Exert Modest Beneficial Actions on Left Ventricular Diastolic Function during Myocardial Ischemia in Dogs1995 · 41 citations
  2. 2Evaluation of myocardial contractility in the chronically instrumented dog with intact autonomic nervous system function: effects of desflurane and isoflurane1993 · 33 citations
  3. 3Influence of Volatile Anesthetics on Myocardial Contractility In Vivo 1991 · 95 citations
  4. 4Volatile Anesthetic Effects on Left Ventricular Relaxation in Swine1990 · 35 citations
  5. 5Desflurane, Sevoflurane, and Isoflurane Affect Left Atrial Active and Passive Mechanical Properties and Impair Left Atrial–Left Ventricular Coupling In Vivo2001 · 38 citations