Monitoring and reversal of direct oral anticoagulants
Population
Patients taking direct oral anticoagulants requiring laboratory measurement or reversal of anticoagulant…
Design
Review
Authors
Discussion
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Member takes
Implication
Specific assays and reversal agents needed for DOAC bleeding; leaves open prospective validation before routine adoption.
Structured PICO
P
Population
Patients taking direct oral anticoagulants (DOACs) requiring laboratory measurement or reversal of anticoagulant effect
I
Intervention
Laboratory monitoring assays (dilute thrombin time, ecarin-based assays, anti-Xa assays) and reversal agents (prothrombin complex concentrate, idarucizumab, andexanet alfa)
Provides a comprehensive overview of appropriate laboratory assays for DOAC quantification and the emerging role of specific reversal agents for severe bleeding.
Cite This Study
Cuker et al. (2015) studied this question.